Cryoprecipitate is particularly rich in which coagulation factors?

Cryoprecipitate is particularly rich in which coagulation factors?

• A. Factor II and Factor VII
• B. Fibrinogen, Factor XIII, and von Willebrand factor
• C. Factor X and Prothrombin
• D. Platelets and Factor VII

Answer: (B)

Cryoprecipitate is a fraction of plasma that is enriched for specific clotting proteins needed to form a stable clot. It is particularly rich in fibrinogen, factor XIII, and von Willebrand factor. Fibrinogen provides the raw material for clot formation, von Willebrand factor helps platelets adhere and also carries and stabilizes factor VIII, and factor XIII cross-links fibrin strands to stabilize the clot. This combination is precisely what cryoprecipitate is designed to deliver. The other options list factors or components that are not concentrated in cryoprecipitate—prothrombin (factor II), factor VII, and factor X are vitamin K–dependent plasma factors not uniquely enriched in cryoprecipitate, and platelets are not part of this product.

Cryoprecipitate is a fraction of plasma that is enriched for specific clotting proteins needed to form a stable clot. It is particularly rich in fibrinogen, factor XIII, and von Willebrand factor. Fibrinogen provides the raw material for clot formation, von Willebrand factor helps platelets adhere and also carries and stabilizes factor VIII, and factor XIII cross-links fibrin strands to stabilize the clot. This combination is precisely what cryoprecipitate is designed to deliver.

The other options list factors or components that are not concentrated in cryoprecipitate—prothrombin (factor II), factor VII, and factor X are vitamin K–dependent plasma factors not uniquely enriched in cryoprecipitate, and platelets are not part of this product.